First baby born after uterus transplant from dead donor


Women who would be candidates for a uterus transplant would have absolute uterine infertility, meaning they don't have a uterus or that it is too damaged to support a pregnancy.

The baby was delivered by way of a Caesarean section on December 15, 2017 at around 36 weeks into the pregnancy.

The recipient had her first menstruation 37 days after the uterus transplant, and continued to have regular cycles after that.

The baby girl was born almost a year ago to a 32-year-old woman who wasn't born with a uterus, according to the report detailed in the medical journal Lancet on Tuesday.

The woman became pregnant through in vitro fertilisation seven months after the transplant.

In a bid to have biological children, she underwent a transplant where she received a 45-year-old woman's uterus after her death. "However, the need for a live donor is a major limitation as donors are rare, typically being willing and eligible family members or close friends", lead author Dani Ejzenberg, a gynecologist at Hospital das Clínicas, University of São Paulo School of Medicine, said in a statement.

Dr. Richard Kennedy, President of the International Federation of Fertility Societies, who was not involved in the work, commented that the organization "welcomes this announcement, which is an anticipated evolution from live donors with clear advantages and the prospect of increasing supply for women with hitherto untreatable infertility".

Performed in 2016 in Brazil, the transplant could provide new hope to thousands of women who are unable to have children due to uterine problems. In Sweden in 2014, doctors for the time time helped a woman with a transplanted uterus give birth; since then, there have been about a dozen such babies born around the world.

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"When a transplant is dome from a live donor, there is a greater responsibility towards both the donor and recipient, but in a dead body the doctors can be a bit relaxed", Ms Sharma said.

But the 10 previous transplants from a dead donor have failed or resulted in miscarriage. "We are focused on improving our protocol to be able to repeat this success story", Ejzenberg said.

The donated uterus was removed during the C-section and the woman's wound healed well, the researchers say.

The surgical team had to connect the donor's uterus with the veins, arteries, ligaments, and vaginal canal of the recipient.

A doctor involved in the transplant said the uterus was preserved in ice for almost eight hours demonstrating the organ's resilience. Dr Falcone said the fact that the transplant was successful after the uterus was preserved in ice for almost eight hours demonstrated how resilient the uterus is.

"This was the most important thing in her life", he told AP.

In the end, they held off an additional month after tests suggested the lining of the donor uterus wasn't quite thick enough to support implantation. But researchers said that if transplant teams can reliably use uteruses from deceased donors, it could expand the availability of organs and reduce living donors' risks during surgery to remove the uterus.

However, he cautioned: "Uterine transplantation is a novel technique and should be regarded as experimental".