Discussing the prosecution's case against the 70-year-old, Commissioner Fuller said "no doubt it will be a voluminous brief with an enormous amount of evidence, and there will be a number of witnesses called." .
Since May, more than 27 million people have listened to The Teacher's Pet podcast, which is produced by The Australian newspaper.
Just before 8am (local time) on Wednesday, Dawson was arrested by Queensland Police detectives in the presence of Strike Force Scriven investigators at Biggera Waters on the Gold Coast. He's now expected to face a Parramatta court on Thursday.
"There was additional evidence that was identified and that has seen the DPP make a positive decision in prosecuting an individual for the murder of Lynette Dawson", Mr Fuller said.
Detective Superintendent Scott Cook said the 70-year-old was "calm and a little bit taken aback" when arrested on Wednesday morning.
In September investigators spent nearly a week digging up the Dawsons' former Bayview home but found no human remains and no significant clues.
"Without a body, without knowing first of all whether in fact she is dead, without knowing secondly if she is dead, how she died, it's very hard to mount a case of a reasonable prospect of conviction just on motive and the undefined existence of means and opportunity".
Fuller said authorities have not located Dawson's body, and that finding her remains is "not crucial to finalising the matter", but maintained "we certainly won't give up on that search".
Mrs Dawson's brother, Greg Simms, said he was "ecstatic" about the development.More news: United Arab Emirates now has world's most powerful passport
"I'm the happiest man alive today, and if Lynette is up there looking down, she'd be smiling at us", he told News Corp Australia.
In 2015, NSW homicide detectives established Strike Force Scriven to reinvestigate the circumstances surrounding Mrs Dawson's disappearance and suspected murder.
Police will use previous interviews they had conducted with Mr Dawson since his wife's disappearance as evidence in the case.
Prior to his wife's disappearance, Chris Dawson and his twin brother Paul had been star players for the Newtown Jets rugby league club.
The cold case gained worldwide attention this year due to The Australian's investigative podcast series The Teacher's Pet.
During his time as a teacher, he met Year 11 student Joanne Curtis.
Magistrate Dennis Kinsella denied Mr Dawson's bail application, saying he was an unacceptable risk of failing to appear.
On the weekend of January 9, 1982, Lyn disappeared. He then waited six weeks to report his wife missing.
Chris Dawson has been arrested over the 1982 death of his wife, Lyn.