The campaign is part of the apparel giant's 30th anniversary Just Do It ad campaign. Dozens of other players began joining Kaepernick, and he has become a symbol of the dividing lines over race in America. It overtly supports Kaepernick's political activism, which involved kneeling during the national anthem, a move that has angered President Trump and his supporters.
The kneeling protest has become a divisive issue within the National Football League, with Donald Trump calling players who kneel "sons of b******".
In 2016 former San Francisco 49ers quarterback Colin Kaepernick took the stance during the American national anthem, as a demonstration against the treatment of black Americans by authorities.
Williams, the tennis legend who also appears in Nike's new campaign, first signed a five-year, $50 million contract with Nike in 2003.
People posted videos and pictures showing them burning their Nike gear or cutting out the iconic swoosh.More news: Is Kevin Spacey off the hook for `92 sexual misconduct allegation?
Many posts included the hashtag #JustBurnIt, a play on Nike's "Just Do It" slogan.
The singer, whose signature hit with the multi-platinum selling Big & Rich is "Save a Horse (Ride a Cowboy)", followed it up saying to watch Nike stock by this time next week and responded to several tweets responding to the cut up socks.
"If they're on the ground early as one of the main corporations targeted by Trump, then if Trump is to flame out. there will be a lot of good will as one of the corporations that stood up to him".
Nike has a history of campaigns that touch on race in the United States.
As a direct result, it has been reported that shares in the Oregon-based Nike Inc. fell more than 2 percent, reportedly as much as around 2.85 percent.