The 31-year-old Serb, making a comeback this year after a slump in form and an elbow injury, said he did not feel he would be a clear favorite in the final, despite his 12 Grand Slam titles - three at Wimbledon.
But they had not shared a Grand Slam stage since Djokovic inflicted a bitter defeat on Nadal at Roland Garros in 2015.
With the win, Anderson will face off against the victor of Nadal-Djokovic match in the final at Wimbledon, with the hopes of winning the first major title of his career. I will not talk more about this. He's seeking his 13th Grand Slam title, and his fourth at Wimbledon. Even Anderson said he could feel during his match that the crowd would rather be watching the next one. It's been a long 15 months for me, trying to overcome different obstacles.
Play will begin at 5.30 pm IST, with the women's final to follow.
Both men go into the final on the back of gruelling semi-finals during which they spent a combined total of nearly 12 hours on court.
In the 50th game, Isner took down the opening point before Anderson captured the next four - including two on aces.
Temperatures are expected to reach about 30C at Wimbledon on Sunday. But I'm proud at how we ended the day. But it is what it is. "I'm definitely going to recover as much as I can to try and be as ready and fresh as possible", Anderson said.More news: Thousands protest in Scotland as Donald Trump hits the golf course
But then the 32-year-old South African is used to building up from humble beginnings, having cut his teeth playing a Futures -level event in Botswana.
I won some great matches, especially in the quarter-finals against Del Potro.
"But when you're planning, you're scheduling, you're second on after 1pm, you don't think you're getting on at 8pm".
Djokovic was looking for his first victory against Nadal on clay.
However, he says he is unsure whether he can described as the favourite to beat Anderson.
Theres no doubt Djokovic will be a big favorite, even if he did need to play almost 2½ hours Saturday while Anderson was able to rest and relax and recover. "He's definitely playing the tennis of his life", Djokovic said.
But the other three Grand Slam tournaments all play on until one player wins by two games. I really feel for him. He's going to come out with big serves and big tennis.
"Fortunately, I was able to find a way over the finish line. We want this match, both of us". He also made the fourth round of the French Open and matched his career-best ranking of No. 9. That should give you a good idea about why some of his matches at Wimbledon, where they do not use a tiebreaker in the fifth set, go on forever.