Local daily La Nuova Sardegna said the 57-year-old Clooney had been headed to a film set on Tuesday when his motorbike was hit by a auto.
The John Paul II hospital in Olbia said the actor was released on Tuesday.
They claim that he injured his pelvis in the smash, but after being x-rayed was sent home.
In the hospital, he was joined by his wife Amal and they left the venue together in a private vehicle.
The Ocean's Eleven actor hurt his leg when a Mercedes vehicle allegedly turned without giving right of way and collided with his scooter, AGI said. AGI said part of the road was closed following the incident.More news: What colour kit will England wear in semi-final vs Croatia?
"Catch 22" is an adaptation of Joseph Heller's classic novel and George is directing and starring in the series.
George and Amal were seen arrive in the island on a private jet at the end of June with their twins Alexander and Ella.
George Clooney was reportedly involved in an accident while riding a motorcycle in Italy.
The couple had previously been enjoying their European trip alongside George's parents Nina and Nick Clooney, as well as Amal's mother Baria Alamuddin.
Sardinia is a large Italian island in the Mediterranean Sea and is over 500 miles from Clooney's villa in Lake Como.