The unusual thing about Weinstein's denial, Hayek noted, was not that he refuted the claims, but that he or his team said anything about them at all - most of Weinstein's sexual abuse accusers have not been directly addressed by the producer.
Hayek also claimed that if there hadn't been as many allegations made against Weinstein, people would have accepted his denial of her accusations.
The disgraced mogul contested her claim, with Hayek insisting it was part of a ploy by his lawyers to try to discredit the "women of colour who complained about him".
At a Women in Motion talk at the Cannes Film Festival yesterday, the #MeToo and Time's Up activist said that if men were serious about fixing the gender pay gap, they would have to take a cut in their own pay.
The actress said of herself and Nyong'o, who accused Weinstein of sexually harassing her back in 2011: "We are the easiest to get discredited".
The 51-year-old said the protest, against female underrepresentation at Cannes and beyond, had been "very meaningful ... as a woman [who] has had to go through all the struggles that all women have to go through".
Only 82 films in competition in the official selection have been directed by women over the past 71 years of the festival whereas 1,645 films have been directed by men.More news: Lethal Weapon: Clayne Crawford Wishes Cast 'Good Luck' After Being Fired
Hayek said inflated fees demanded by some leading actors, whom she did not name, could mean there was less money left for their female co-stars.
The initiative has been taken up by French gender equality movement 5050x2020 that aims to highlight the hurdles that women have to cross to be able to climb up the professional and social ladder in the film industry.
"Time's up. You had a good run but it is time now to be generous with the actresses", she added. More than angrier, because I think we were already angry.
In December, Hayek joined the list of more than 40 women who came forward with allegations of sexual harassment against Weinstein.
So hard, in fact, "otherwise they will kill the movie", Hayek quipped.
In the wake of the scandals that have followed Weinstein's downfall, Hayek said men in Hollywood "are terrified" and that "predators are hiding". "Men have the opportunity, which is so lovely, to rethink what does it mean to be a man", she said.
"We should have come together, because that's what's made a difference".