Trump did eventually order the closure of the Russian consulate in Seattle and the expulsion of 60 Russian diplomats over the incident.
The statement also condemned the air strikes on Syria where its armed forces are backing regime leader Bashar al-Assad.
'We can not allow the use of chemical weapons to become normalised - within Syria, on the streets of the United Kingdom, or anywhere else in our world. He added that the Russian military has proof of British involvement, but didn't immediately present it.
Moscow's threat to down USA missiles came from its ambassador to Lebanon, Alexander Zasypkin, who said it was based on previous statements by President Vladimir Putin and the Russian armed forces chief of staff. He didn't elaborate or name the state.
But this unfolded in the context of what appears to be presidential ambivalence about the Russian Federation threat.
Russian Federation deployed its military forces in Syria, showing their allegiance to the Assad regime.
According to a statement by the French presidency, Macron called for dialogue between France and Russian Federation to "continue and intensify" to bring peace and stability to Syria.
"The most important thing is to refrain from ill-considered and unsafe actions that would constitute a gross violation of the UN Charter and would have unpredictable consequences", the office of the president said in a statement after the call.
Nebenzia told reporters after a closed emergency meeting of the U.N. Security Council on Thursday that "the danger of escalation is higher than simply Syria, because our military is there on the invitation of the Syrian government".
"I spoke to the president this morning, and he said, 'If the Syrian regime uses this poisonous gas again, the United States is locked and loaded, '" Nikki Haley said at an emergency U.N. Security Council meeting called by Russian Federation after the USA and allies struck three targets in Syria.
"This is grotesque, it is a blatant lie, it is the worst piece of fake news we've yet seen from the Russian propaganda machine", Pierce told reporters.
Some national leaders appeared anxious to avert a showdown between the U.S. and Russian Federation.
Russia's United Nations ambassador warned that US-led strikes could lead to a confrontation between the world's two preeminent nuclear powers.More news: F1: Ferrari's (NYSE:RACE) Sebastian Vettel On The Pole at Shanghai
Russian officials had said before the suspected gas attack in Douma that rebels in the eastern Ghouta suburbs of Damascus were plotting chemical attacks to blame the Syrian government and set the stage for a US strike. They had been expected to start their investigation into the alleged Douma attack on Saturday.
Russian Foreign Minister Sergei Lavrov said earlier that Moscow was in contact with Washington to discuss an atmosphere he described as alarming. The ministry additionally pointed to previous alleged use of chemicals by the rebels in fighting with Syrian government troops.
"Certainly for domestic consumption they've got to look like they're not rolling over for Israel, for the United States or for France or whoever else". "I hope no one would dare to launch such an adventure now", Lavrov said.
The Russian military has also made belligerent statements, but Putin himself and the Moscow foreign ministry have instead played the injured party, demanding proof of Assad's culpability.
During a phone call late on Thursday, UK Prime Minister Theresa May and US President Donald Trump agreed on the need to deter chemical weapon use in Syria.
Alexey Malashenko, a specialist in the Syria conflict, said Washington and Moscow were more likely to remain engaged in a war of words.
"Mission Accomplished!" he tweeted Saturday.
The US "specifically identified" targets to "mitigate the risk of Russian forces being involved", Dunford said.
There is a heightened "danger of escalation" because of the Russian military presence in Syria, Nebenzia said after a private meeting of the UN Security Council in NY. It said another attack with "a number of missiles" targeting a scientific research center destroyed a building and caused other material damage but no human losses.
"The immediate priority is to avert the danger of war", Russia's United Nations ambassador Vassily Nebenzia said on Thursday.
The measures announced by the Treasury Department were also aimed at 17 senior Russian government officials and the state-owned Russian weapons trading company, Rosoboronexport, which has long-standing ties to Syria and its subsidiary, Russian Financial Corporation Bank.
If confirmed, the town's seizure would mark the last stage of Assad's takeover of the rebel-held enclave of eastern Ghouta.
The capture of Douma has clinched a major victory for Mr Assad, crushing what was once a centre of the insurgency near Damascus, and underlines his unassailable position in the war, which entered its eighth year last month.