The building also contains the headquarters of the World Wildlife Fund, an environmentalist group.
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Fox 5 DC reports that police were called to Obama's office building shortly after noon over concerns about white powder that had been sent to it through the mail.
It isn't clear if Obama, who resides in the nearby Kalorama neighborhood, was in the office when the package arrived.
The surrounding area has been closed to traffic and will remain so until the investigation wraps up.More news: Iraqi intelligence official claims Daesh ringleader Baghdadi 'alive' in Syria
The incident comes just one day after a white substance was sent along with a threatening note to Donald Trump Jr's wife in NY. "Whatever the substance was, it was deemed to be nonhazardous".
This comes just a day after Donald Trump's daughter-in-law Vanessa Trump was sent to hospital after a letter containing a similar "suspicious substance" was sent to her apartment in NY. Peter Donald, according to ABC News.
The Secret Service continues to investigate the WWF building incident.
The letter read: 'You're an bad person and now you get what you deserve'. The powder turned out to be cornstarch.
In 2001 22 people were infected and five people died after letters containing the spores were sent to several news media offices and two Democratic senators: Tom Daschle of South Dakota and Patrick Leahy of Vermont.