But her hopeful message - "A new day is on the horizon" - could have doubled as a campaign rallying cry.
But the strongest indication to date that Winfrey is thinking about her political future came Sunday evening as she accepted the Cecil B. DeMille award, speaking not about herself or any election, but about the #MeToo movement.
You can read the full text of Oprah's speech that fired up the Golden Globes HERE.
She indicated that the same thought had crossed her mind after Trump's election: "I thought, 'Oh gee, I don't have the experience, I don't know enough.' And now I'm thinking, 'Oh".
The TV mogul and philanthropist took the moment to deliver the most moving-and important-speech of the night, in which she addressed the rampant sexual harassment and abuse allegations that plagued Hollywood in 2017, and how the tide is hopefully turning.
She also hailed the role of the media, so often maligned by Trump as "fake news".More news: Golden Globes 2018: Emma Watson walks in all black
"Oprah", Meyers said, looking out at her in the audience, "in 2011, I told some jokes about our current president at the White House Correspondents Dinner - jokes about how he was unqualified to be president - and some have said that night convinced him to run".
'So if that's true, I just want to say - Oprah, you will never be President! "She would absolutely do it".
Hollywood's loathing of Trump and bafflement that a crass-talking reality star with no previous government experience could win the presidency have fueled talk of well, why not another television star, only one with the "right" politics?
Winfrey, an early supporter of President Obama, endorsed Hillary Clinton in the 2016 presidential race, telling ABC News at the time, "I'm with her". "Hi, Oprah", the awestruck Marvelous Mrs. Maisel star Rachel Brosnahan said when she arrive on stage to accept her award. The moment, a highlight of the night, was the most talked-about speech, with Monday morning news show debating the chances that Winfrey will actually run. "You do not have what it takes", Meyers said, while also proposing actor Tom Hanks as a vice presidential candidate. Winfrey's mentions on Twitter, including "she's running", are approaching almost one million, according to data from the social media site.
"It was somewhere in Rosa Parks" heart nearly 11 years later when she made the decision to stay seated on that bus in Montgomery", Winfrey said. He called her "sounder on economics than Bernie Sanders, understands Middle America better than Elizabeth Warren, less touchy-feely than Joe Biden, more pleasant than Andrew Cuomo, more charismatic than John Hickenlooper". I don't think she had any intention.