The 405 is closed in both directions from the 10 to the 101. People who live in Mandeville and Sullivan canyons should be prepared to leave their homes, authorities said.
More than 220 firefighters are on the scene, with assistance from a water-dropping helicopter from the Los Angeles County Fire Department.
As of press time, the fire is heading from the east toward the Getty Center and toward UCLA.
The 50-acre fire was first reported at about 4:50 a.m. on the east side of the northbound lanes, where there are a number of schools and condominium complexes, across the freeway from Skirball Center Drive.
It was reported at six acres but quickly grew to at least 50 acres as crews were working against 25 miles per hour winds. "It's critical residents stay ready and evacuate immediately if told to do so".More news: Stephen Curry on Crutches After Late-Game Ankle Injury
Nearly 200,000 people lost power in Ventura County on Tuesday, making it challenging for the 1,100 firefighters to put out the flames. The mayor declared a local state of emergency in response to the Skirball Fire, as he had done Tuesday in connection with the 11,000-acre Creek Fire near Sylmar and Lake View Terrace. Meanwhile, other major wildfires were burning in other parts of the Southland, including the 65,000-acre Thomas fire in Ventura County and the 7,000-acre Rye Fire in the Santa Clarita area.
Southern California faces another day of horrifying fire and destruction as the devastating Skirball fire moves west toward Los Angeles.
"This has only just begun", said Terrazas.
Strong winds were hindering the deployment of firefighting aircraft, according to fire officials.
A red-flag warning, which is for extreme weather conditions that could cause wildfires, is in effect until 8 p.m. PT Friday.