Garda forensic collision investigators are to continue their examination of the scene this morning, and detectives say the road is likely to remain closed until lunchtime at the earliest.
Gardai have confirmed that three men and a woman lost their lives in the crash.
Locals described the scene as "absolutely horrific" with debris scattered all over the roadside.
The collision occurred on the N25 New Ross to Ballinaboola road at Begerin Hill (approximately 2-3 miles from Ballinaboule).
The scene of the crash remains sealed off by police who have closed a section of the N25 near Cushinstown.
Paramedics desperately tried to stabilise the condition of two critically injured people.More news: Cyclone Ockhi: Maha, Guj on high alert; Kerala toll at 25
Emergency services cut open the auto to free them but they were all pronounced dead at the scene. But all four were pronounced dead at the scene, and their bodies were later removed by ambulance to University Hospital Waterford in Ardkeen for postmortems.
New Ross in Wexford is a popular stop for many USA tourists because of the Dunbrody starvation ship and the area's famous links to President John F Kennedy.
The collision happened at 6.30pm this evening..
The lorry driver and a passenger in the lorry avoided serious injury.
"Did he look over the wrong shoulder", wondered a first responder on the scene yesterday, noting the driver would have been more used to driving on a different side of the road in the US.
The fatal road collision between a vehicle and a lorry occurred on the N25 near New Ross, gardai said.