It's a busy two months when things can change.
"At the moment we are on an up".
De Bruyne, who played an instrumental part in City's winning goal against West Ham on Sunday reckons this derby will not one to miss, with United looking to close the gap between the two Manchester clubs.
'Hopefully, we can win the game, that would be massive. "I wish them all the best and hope they can win a lot of trophies".
"They will be up for it and we will be up for it". So far, that's seen us win games, so that's good'.
City's hopes of a record breaking 14th straight win in a season have been boosted by Paul Pogba's suspension for his sending off at Arsenal.More news: Gamecocks going to Tampa for Outback Bowl, taking on MI
But De Bruyne doesn't think Pogba's absence at Old Trafford is down to bad karma.
"I don't believe in that s***", he said bluntly. If someone believes it is karma then OK, everyone has their right to their opinion.
He said: "Maybe (it is) good for me to get a little bit of rest and prepare myself for Sunday". "It's a competition, you want to play against the best teams and the best players". We need to keep focused and continue that'.
Before the derby, City face a trip to Ukraine to play Shakhtar Donetsk in their final Champions League group game, having already qualified for the knockout stages.
'Now I mentioned City's greatest ever players, all the City fans may say Colin Bell, I don't know but in David Silva, he is the greatest City one.
Meanwhile, the FA will not take any action against City boss Pep Guardiola for his pitch invasion against Southampton last week.