This would mean that Spurs would have to sell one of their best left backs, Danny Rose coming under fire for his performances and immediately attracting interest from top English clubs including Manchester United.
Mourinho's side are eight points behind Pep Guardiola's Premier League leaders going into this weekend fixtures.
"I play a game at a time and I think it's the way to do it", he said. The Gunners have been fantastic at home in this campaign as they won all seven Premier League matches at Emirates, scoring 20 and allowing only four goals in the process.
The Red Devils will play 10 games in December as the hectic Christmas schedule returns.
The 24-year-old recently returned to the United side and his comeback has coincided with an upturn in form for Jose Mourinho's side.More news: LeBron James Ejected for First Time in NBA Career
"I don't know if he can play", Mourinho said on Friday.
The France global made his comeback last month and has played an influential role in a run of three straight Premier League wins ahead of Saturday's trip to Arsenal. The magpies have lost four of their last five, overturning a two-goal deficit to snatch a point against West Brom in midweek to seal their sole point from the last 15 available. Mourinho will be without the midfielder Michael Carrick who is out with a calf injury and will not feature on Saturday, while the centre-back Eric Bailly is still struggling with a knock and will probably be unavailable for this tilt.
One player who could get a chance to impress Jose Mourinho with Matic set to miss the game is Ander Herrera, with the player the key cog in the midfield last season, only to see his place in the side diminished after the Chelsea man arrived.
The bad blood runs deep between Mourinho and Wenger, with the latter yet to forgive the Portuguese for labelling him a "specialist in failure" in 2014 when he coached Chelsea.