All told, the Senegal worldwide is expected to miss at least nine matches in the league and Europe after being taken off late in the second half during Saturday's 2-0 win over Cape Verde.
Liverpool have ruled Sadio Mane out for up to six weeks with a hamstring injury, a significant blow ahead of Saturday's clash against Manchester United.
"And it has now been confirmed that he picked up an injury during that fixture that could keep him out of action for up to six weeks".More news: Minnesota Man Who Helped Kidnapped Teen Gives Her His $7K Reward
Senegal, who are top of their World Cup qualifying group, face two crucial games against South Africa on 10 and 14 November, which Mane is also likely to miss.
Mane has netted three goals for the Reds so far this season and is behind just Mohamed Salah and Roberto Firmino in the scoring charts.
Since the start of last season with Mane in the team, they have won 19 of 32 Premier League games and averaged 2.2 goals and 2.1 points per match in the process.