It also came four plays after Odell Beckham Jr. hurt an ankle and become the fourth Giants receiver knocked out of the game. The scene itself was of OBJ in tears after players on the field called for medical attention immediately following a play in which he landed awkwardly on his left leg.
Beckham's ankle was trapped under a Chargers defender he crumbled to the ground. He had his left cleat off as he was taken to the locker room on the cart.More news: Congress DPCC unit passes resolution asking Rahul Gandhi as new party president
Marshall suffered a sprained ankle, according to ESPN's Adam Schefter.
Shepard was injured when he was hit hard over the middle earlier on the same drive. His 48-yard grab during the game gave him back-to-back performances with a catch of 40 yards or longer. He had two catches for 15 yards before leaving Sunday with the injury. The Chargers, though, scored the final 10 points of the first half on a 6-yard touchdown pass to Gordon and a 20-yard field goal with six seconds left.