Wentz (21-of-30, 304 yards, 4 TDs, INT) established a personal best with four touchdown passes - three of which came on consecutive pass attempts in the first quarter.
Fitzgerald became the third player in National Football League history to catch a pass in 200 consecutive games. Running back LeGarrette Blount had another strong outing, carrying the ball going for 74 yards on 14 carries.
It was a statement win for the now 4-1 Eagles against a team that typically gives them fits - or Fitz.
Alshon Jeffery didn't appear to be running at full speed on a deep pass that landed just out of his reach and likely would have been good for a touchdown in the second quarter. The statistical fruits of that growth came at the Cardinals' expense.
After forcing the Cardinals to punt, Kenjon Barner sparked the Eagles with a dazzling 76-yard return.
Thanks to Barner's return, it took the Eagles about 90 seconds to score again.More news: All Blacks pip the Springboks in tight affair: Reaction from Twitter
Against the Eagles, they managed to rush for only 31 yards on 14 attempts, an average of 2.2 yards per carry.
In a game with highlight after highlight, nothing was better than the team's first quarter touchdown celebration after a Torrey Smith strike.
On the Eagles' first drive, Wentz capped a 10-play, 54-yard drive with a 15-yard touchdown pass to Trey Burton in the corner of the end zone for a 7-0 lead. Palmer was hit seven times by the Eagles defense, being sacked two times for a loss of 15 yards.
With less than a minute to go in the half, Wentz threw his first interception since Week 2 after his pass intended for Ertz was picked off by Antoine Bethea in the end zone.
In all, every position group seemed comfortable and potent defensively, as Philly allowed just 279 yards total (31 rushing)- with many coming in garbage time late in the game.
Agholor finished the day with a career-high 93 yards, including a 72-yard touchdown reception in the third quarter to put the game away for the Eagles. He celebrated his first TD as an Eagle by pretending to be a baseball player hitting a home run.
Kicker Phil Dawson had a 51-yard field goal blocked by Patrick Robinson on the final play of the first half. He stopped at the goal line, then did a back splash into the end zone. Philadelphia faces a short turnaround with a Thursday night matchup at Carolina.