The fifth and final one-day global proved a somewhat low-key affair, with England already holding an unassailable series lead and headlines being dominated by off-field matters following Stokes' arrest in the early hours of Monday morning.
What lies ahead during his next assignment in Australia this winter, especially if Stokes is absent, will be a completely different, and infinitely tougher, challenge than this.
Rashid would finish with figures of 1-42 off his 10 overs while Ali would return with 1-36 off his complete quota to take the edge off the visitors' batting.
Roy was well on course for his fourth worldwide hundred but unfortunately fell just four-runs short of the mark after missing a straight delivery from medium-pacer Miguel Cummins to be trapped plumb on the pads.
By the time Gayle departed for 40, West Indies were 52 for one in the eighth over.
That brought the Hope brothers, Kyle and Shai, together in the middle and while the explosive power of Gayle was lacking, there were the beginnings of an encouraging partnership before another fine catch from Plunkett cut it short.
Hope reached his half-century, in 79 balls, with successive fours in the 39th over.More news: Officials feared White House counsel would quit over Trump-Kushner meetings
Opener Evin Lewis has been ruled out of today's fifth ODI after picking up a hairline fracture of his ankle during the fourth game on Wednesday and regular captain Jason Holder has returned home to Barbados for the funeral of his uncle.
Hope then departed for 72 when he skied Ball to Sam Billings in the deep, West Indies now 221 for five.
Debutant Sunil Ambris [38 not out] and Ashley Nurse [31 not out] played a role in scoring 115 from the final 12 overs but could only take the West Indies to 288 for 6 from their full allocation.
Ben Stokes and Alex Hales are both missing after grabbing the headlines for the wrong reasons since the weekend. However, he was unexpectedly trapped lbw by Miguel Cummins in the 22nd over, bringing Joe Root to the crease.
England never looked in danger of throwing this one away once Roy, who had posted 84 during England's win at The Oval on Wednesday, helped them get off to a flier.
Alongside new partner Root, Bairstow continued to make hay as England's target crept ever closer.
Bairstow reached a fifty of his own in 48 balls and by the end of 21 overs, England were 154 for naught. His hundred came up off just 90 balls.