Johnson's x-rays came back negative, but the wrist sprain still could keep him out for an extended period.
Johnson finished last season with 1,239 rushing yards and 16 touchdowns.
Arizona running back David Johnson dislocated a wrist, Cardinals Coach Bruce Arians said, and probably will require surgery. His 120 targets in the passing game were 26 more than Le'Veon Bell for the most among running backs.
The second opinion is in, and it's bad news for the Arizona Cardinals.
Johnson is expected to undergo further testing on Tuesday.More news: Tarleton releases statement about DACA program ending
The Arizona Cardinals are bringing back veteran running back Chris Johnson, according to the Associated Press' Robert Baum. Johnson's workload in 2015 was significantly more substantial, as he had just shy of 200 carries for over 800 yards. Chris Johnson was released in the Cardinals' final roster cuts.
Schefter added Johnson still has a chance to return this season. Johnson earned All-Pro honors a year ago in his first full season as a starter, rushing for 1,239 yards and 16 touchdowns in 2016 and adding 879 yards and four TDs receiving.
"Andre [Ellington] looked very good".
Ellington said there has been no talk about how the playing time would be distributed going forward. Johnson went down in pain, but got up and tried to play. It's an opportunity for somebody to step up. Certainly, a wrist ligament could have been injured and not seen on video, but that type of injury doesn't happen with a direct blow.