It was a curiously anti-climactic way for the final to end, as Muguruza sank to knees in tears, becoming the second Spanish woman since her stand-in coach Conchita Martinez to win the title.
The two went toe-to-toe in the first set, with neither looking likely to blink first until Muguruza saved three break points, including two tension-filled set points in the 10th game, before cutting lose to win her second grand slam title.
The Spaniard slammed a bullet of a down-the-line return victor that landed smack in the corner to break for 3-0 in the second set, then immediately walked to her bench, nearly before the ball had touched the ground, and without once taking a glance at her opponent.
A first grand slam title did come her way in 2016, though, as she got some revenge on Serena by lifting the French Open at the American's expense. "I was watching Venus", Muguruza, who is the only player to have beaten both Williams sisters in a Grand Slam final, told ESPN. Only those who have played professional sport can know what that moment of decision feels like. I played very well since the first game, and I kept the level, which is very hard because, you know, you're, like, nervous.
There was nearly nothing to separate the pair in a high-quality first set, and it was Williams who had the first sniff with two set points at 5-4.
The opening set was a competitive affair filled with grueling rallies and hard-fought points.
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Williams would not win another game and the match ended in the most anticlimactic of manners when Williams hit a shot that landed long, but was ruled in. The fact that she made it this far, at this stage of her career, is enough for me to smile at and give thanks for.
"I think she played wonderful".
Maybe Muguruza doesn't know why either, but it's imperative for her to figure it out post-Wimbledon, because surely waiting another 12 months to get to another final is not a scenario she'd want to go through again.
"I think she played wonderful". Taking the ball early, being aggressive from the start of each point and not relenting, Muguruza did to Williams what the American and her sibling often do to their opponents. She just dug in there and managed to play better. I came thinking, I'm prepared, I feel good.
But Muguruza saved them both and did not look back, committing fully to her game plan, defending superbly when needed and not letting her focus slip for a minute.
Muguruza said: "Eastbourne was such a short tournament, I didn't play well there. I tried my best to do the things you do - but I think there will be other opportunities". So I was calm.
She looked strong, confident and determined, living with the pace and power from Muguruza to earn a couple of backhand errors and two break points, set points, but could not convert. I lost that final (2015). "I believe I can". I've had a great two weeks. "So this is where I want to be every single major", she said.