Ronaldo stunned the footballing world after news emerged last week that the Portuguese superstar wants to leave Spain after being upset by his treatment over accusations of £13m tax fraud. "All this is very unusual", Perez told the Spanish radio station Onda Cero, as quoted by Sky Sports.
"Ronaldo is a lot more powerful and more important than all of us who are here", he added.
The 70-year-old, who was re-elected in 2009 having previously held the post between 2000-06, is the second most successful president in Real's history in terms of football trophies won during his tenure, behind only Santiago Bernabeu who served between 1943 and 1978 and who the club's stadium is named after.
Prosecutors in Madrid have filed a complaint in which they accused Ronaldo of a "voluntary" and "conscious" breach of his tax obligations, amounting to a figure of €14.7million.
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Perez's expensive and ambitious "Galacticos" project, which later brought the likes of Frenchman Zinedine Zidane, now Real's manager, England's David Beckham and Brazil's Ronaldo to the club, had initial success but ended with the team floundering on the pitch, prompting his resignation in February 2006.
Although United would want to be involved in any discussion over Ronaldo's future, if he does eventually try to force his way out, they are pressing ahead with the transfer plans they already have in place for now.
Since extending his contract in November until 2021, Ronaldo is according to Forbes the highest paid sports star in the world with US$93 million in 2016-2017.
Perez also confirmed that no club has made an offer for the 32-year-old, who has a release clause of £1 billion.
"We're used to being the subject of intense transfer speculation during transfer windows", Rummenigge said in a statement. As a rule, we do not comment on these rumours.
The Portuguese worldwide, who lifted the Champions League for a second season on the bounce earlier this month, scored 118 goals in 291 appearances for the Red Devils, winning three Premier League titles, two League Cups, an FA Cup and the Champions League, as well as the first of his Ballon d'Or's.