Four goals from Harry Kane and a brace from Son Heung Min have helped Tottenham to a 6-1 win over last season's Premier League champions Leicester City.
Spurs travel to the Tigers on Sunday while Lukaku and Arsenal's Alexis Sanchez, who is the only other player with a realistic chance of winning the award, are set to go head-to-head at the Emirates.
Kane averages a goal every 94 minutes in the league this season, and unsurprisingly described the campaign as his best yet.
Foreshadowing their imminent goal spree, Tottenham started with a swagger and almost took the lead when Kane's pass picked out Son, only for Chilwell to deny him with a last-ditch block.
The away fans" cries of "we want six' were rewarded in stoppage time, as Kane scored a fourth, which was basically the exact same goal as his third, to finish the rout for the visitors.
Tottenham moved to 83 points on the season, two more than Leicester's title-winning total a year ago.
And there was enough time for Kane to take his tally to four and move top of the league's goalscoring charts outright.
And Leicester manager Craig Shakespeare admitted there was little to take from defeat after the Foxes suffered their heaviest home league loss since 2004.More news: Motorola launches Moto C and Moto C Plus smartphones
"We have to improve the squad again and try next season and the season after to not only keep the performance but to win some trophies".
Shakespeare switched his side to a back three for the second half and the change triggered a response, with Mahrez testing Lloris from 20 yards and Marc Albrighton seeing a promising opening snuffed out by a fine Eric Dier block.
Dele Alli's low header was then saved by Leicester goalkeeper Kasper Schmeichel as Spurs began to raise the tempo, sensing Leicester was there for the taking. Spurs' keeper, Lloris, had rushed out of his box to clear the ball.
The victory had little effect for Spurs who are guaranteed second place, although Leicester's 18th defeat of the season equalled Liverpool's top-flight record, set in 1906-07, for reigning champions in a 38-game campaign. He is great, he is one of the best strikers in the world.
Kane headed in from point-blank range after more neat work from Son and the South Korean grabbed his own double on 71 minutes. I don't know how long he had an injury but he's still scored 26 goals.
To further rub salt in the wounds, Pochettino then brought on Vincent Janssen, having opted to start with fellow transfer flop Moussa Sissoko, who had spent most of the first half asking to be substituted, after an apparent illness, before playing the rest of the match.
"I think this will be a good game".