Officials said five cars of the 12-car train derailed northeast of the Rye station, which is on the New Haven line.
A Metro-North train jumped off the rails in Westchester Thursday.
Metro-North says the train left the Stamford, Connecticut station at 4:31 p.m. with about 185 people on board.
The train was scheduled to get into Grand Central at 5.42pm, officials said.More news: Applied Materials Inc (NASDAQ:AMAT) Institutional Investors Quarterly Sentiment
Westchester County Executive Rob Astorino said early reports show the train may have been speeding around a curve. Crews were working throughout the night to remove the damaged auto and fix the track in time for the morning rush.
A tragic Bronx derailment caused by a sleeping conductor killed four and injured 63 on the service's Hudson Line in 2013.
Two weeks before that derailment, an Amtrak train had a slow-speed derailment on Track 6 at Penn Station.
Thursday's derailment ended a relatively smooth ride for Metro-North following a series of accidents and bridge closures that affected thousands of commuters.