Jose Mourinho kissed a lucky charm just minutes before Manchester United scored their victor against Anderlecht.
Rojo's injury leaves United potentially short in defence as Phil Jones and Chris Smalling are sidelined.
Striker Zlatan Ibrahimovic also suffered a major injury, and it's possible that the Swedish superstar may have played his final game in a United shirt.
"Because for the team they have to do everything, that's the way I think, we can not do miracles, so miracles I do not expect but we have to try to do everything to accelerate the process. I'm just a manager not a doctor", Mourhino said when asked about the seriousness of the injuries.
United issued a statement concerning disaster on Friday morning, tweeting: "Our thoughts go out to the United fans, their friends and families affected by the tragedy in Calabar, Nigeria, yesterday".
Henrikh Mkhitaryan opened scoring for Mourinho's team, before Sofiane Hanni equalized for the visitors.More news: Martial has to start doing what I like, warns Mourinho
Rashford scored an extra-time victor in a 2-1 victory over Anderlecht to send United into the semi-finals of the Europa League on Thursday, hitting his third goal in his last four appearances.
Regarding 19-year-old Rashford, Mourinho said: "It is hard for the kid to play every match, but I always trust the players with special mentalities".
"We have (Eric) Bailly and (Daley) Blind who have experience and it's time for Jones and Smalling to be courageous - to (take a) risk - because for the team you have to do everything". They can not make miracles, they have injuries and even in a insane mentality they can not play Sunday.
Manchester United switch their focus back to the Premier League as they travel to Burnley on Sunday (14:15 BST) before travelling to Manchester City on 27 April (20:00).
No problem if you need to make a change in another position, do it because I am ready for it'.
"I'd love to see them both", he added.