Chelsea do face a tough away trip to Goodison Park, where Everton's home record is brilliant, and the Blues know the pressure is now on with Spurs only four points behind them in the title race.
Facing his former club, Mourinho rested top scorer Zlatan Ibrahimovic and charged Ander Herrera and Matteo Darmian with the task of man-marking Chelsea dangermen Eden Hazard and Pedro.
The Red Devils beat Chelsea 2-0 yesterday and are now four points behind fourth-place Manchester City with a game in hand as they strive to secure Champions League football.
"We have a lot of match-winners".
Mourinho is quoted as saying by Metro: "We need more quality, but in terms of character and the human side I have one of the best groups ever".
But Mourinho and his United players proved a big point yesterday when they deservedly put Chelsea to bed and the Special One has explained just how they did it.
"And nobody can criticise us if in the last matches of the league we do it in a different way, but while it's mathematically possible we have to go with everything we have".More news: Jason Chaffetz Won't Seek Re-Election, Utah Governor Run Rumors Persist
"I think it was nearly ideal", Herrera said.
Fabregas was booked for a foul on Carrick as United ran down the clock on a day that gave them, and Mourinho, revenge for two defeats at Stamford Bridge earlier in the season.
It must be said the electric Marcus Rashford was a major difference too, offering a counter-attacking threat in behind for the home side that left Chelsea petrified all game long.
"The league is open and we have a 50 percent (chance) to win the league", said Chelsea manager Antonio Conte, who blamed himself for the loss to United.
Darmian added: "We know that it will be a hard game but we play at home, in front of our fans. Nobody can doubt our credit to win the game".
Gary Cahill expects a quick response from Chelsea after revealing the squad was angry after their defeat at Manchester United on Sunday. It is very simple but in this case the fault is of the coach. It is mine. In this case I wasn't able to do the right motivation.
"Tottenham is in good form and playing with enthusiasm, we must find the same".