After almost two decades as Fox News' most popular host, Bill O'Reilly, 67, was let go Wednesday by parent company 21st Century Fox.
He will be replaced in the prime-time lineup by Fox host Tucker Carlson.
Eric Bolling, now a host of "The Five", will get his own show airing during the 5 p.m. hour.
The O'Reilly Factor is the top-rated show on Fox News.
But the climate shifted dramatically after The New York Times reported on April 1 that O'Reilly or Fox had paid $13 million to settle five cases against him alleging sexual or other harassment. His trip came as Fox News Channel's parent company 21st Century Fox is investigating sexual harassment allegations against him.
"After a thorough and careful review of the allegations, the Company and Bill O'Reilly have agreed that Bill O'Reilly will not be returning to the Fox News Channel", Efe news agency quoted the network's parent company as saying in a statement.
There was no immediate response from Bill O'Reilly's bosses Wednesday to escalating reports that the Fox News Channel personality will lose his job following accusations he had harassed women.
Fox has lost multiple stars and executives in the previous year.
The harassment complaints are on top of separate allegations against Roger Ailes, Fox News' co-founder. Olbermann said that when he was working at Fox Sports in 1999, he helped a friend get a job at Fox News.More news: China says Ivanka Trump trademark requests handled properly
O'Reilly's sudden departure from Fox News arrives after over 50 advertisers pulled their ads from the news network.
A security guard looks out of the the News Corp. headquarters in Midtown Manhattan, Wednesday, April 19, 2017. Some bestsellers include "Old School: Life in the Sane Lane", "The O'Reilly Factor: The Good, the Bad, and the Completely Ridiculous in American Life", "The No Spin Zone", "Killing Lincoln", "Things That Matter: Three Decades of Passions, Pastimes and Politics" and "Killing Jesus".
Kasowitz also said "irrefutable" evidence would soon reveal "that the smear campaign is being orchestrated by far -left organizations bent on destroying O'Reilly for political and financial reasons".
Noting the "dramatic changes", Perino said: "It is the end of the era".
It's also home to ambitions that the O'Reilly crisis may have hindered.
O'Reilly and President Donald Trump are both "crowd-pleasing showmen who know how to signal to loyalists in their audience that they are not taking themselves quite as seriously as their detractors are", said news consultant Andrew Tyndall.
On Wednesday, he was seated in the VIP section, where a photographer from the Vatican newspaper L'Osservatore Romano snapped a photo of Francis reaching out to shake his hand.
This story has been corrected to show that the downfall of O'Reilly began with an April 1, not April 2 report in The New York Times.